Application fields of PGA

Biodegradable essentially means an item can be broken down into smaller and smaller pieces by bacteria, fungi or microorganisms and reabsorbed by the surrounding environment, ideally without causing any contamination. Some things are naturally biodegradable, such as food and plants, while other items can break down into harmful chemicals or gases.

 

Polyglycolide is a biodegradable plastic, which means it breaks down through natural processes, making it a more environmentally friendly option than traditional plastics. PGA is commonly used in medical applications such as sutures and wound dressings due to its strength, biocompatibility, and absorbability.Polyglycolide is also used in agriculture, such as as mulch to help retain moisture and control weeds. Hence, its versatile usage in different end-user industries is driving the demand for PGA. Advances in PGA production technology have reduced costs and improved quality, making it easier to enter a wider range of industries.

Biodegradable polymers are currently of great interest in many applications. This degradable polymer is important for the future of sustainable polymers and plastics, such as solving end-of-life issues and finding pathways for recycling. An important part of scientists’ research in recent years has been devoted to biodegradable polymers in the biomedical field, such as PGA, PLA and PLGA (e.g. for use in drug and gene delivery systems, bioengineering scaffolds or as bioadhesives)

PGA has been known since 1954 but has had little use because it is susceptible to hydrolysis compared to other synthetic polymers. However, in 1962, this polymer was used to develop the first synthetic absorbable suture.

Polyglycolide sutures are synthetic, absorbable, braided multifilament. It’s coated with N-lauric acid and L-lysine, making the threads extremely smooth, soft and knot-safe. It is also coated with magnesium stearate and finally sterilized with ethylene oxide gas. It degrades naturally in the body through hydrolysis and is absorbed as water-soluble monomers, a process that takes between 60 and 90 days. Elderly, anemic, and malnourished patients may absorb sutures more quickly. It has the advantages of high initial tensile strength, smooth tissue passage, easy operation, excellent knotting ability, and strong knotting. Commonly used for subcutaneous suturing, intradermal closure, abdominal and thoracic surgery.

The traditional role of PGA as a biodegradable suture material has led to its evaluation in other biomedical fields. Implantable medical devices have been produced using PGA, including anastomotic rings, needles, rods, plates, and screws. It is also being explored for use in tissue engineering or controlled drug delivery. Tissue engineering scaffolds made of polyglycolide can be produced by different methods, but usually most are obtained by textile technology in the form of non-woven mats.

PGA is much less reactive than regular gut or chromic gut, and in experiments was better able to resist infection from bacteria. contaminating bacteria. Multiple in vitro and in vivo studies have shown that PGA and polyester PLA have sufficient biocompatibility. PGA is also used in wound healing and adhesives. Polyglycolide successfully adhered to the wound, helping to prevent postoperative bleeding and promote epithelialization. These sheets were initially used only on soft tissue and later on hard tissue as well. PGA as an adhesive, PGA combined with fibrin sealant creates a very successful tissue adhesive. The combination of PGA and fibrin creates a stronger sealant than any other combination of biomaterials.

Polyglycolic acid (PGA) Product features and advantages of polylactic acid: Biodegradable aliphatic polymer with fast degradation rate; good biocompatibility; biodegradation mainly through simple hydrolysis; bioresorbability; good processing Performance; Glycolic acid polymer PGA and its copolymers with different molecular weights can achieve degradation rates, physical properties, mechanical properties and other properties. Polyglycolic acid is mainly used in sutures for cell culture, transplantation, organ regeneration, drug delivery carriers, stents, and polyglycolide-caprolactone sutures/polyglycolide sutures.

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