What is PLLA

PLLA is an important biodegradable polymer material, which is characterized by non-toxic, non-irritating, biodegradable absorption, high strength, good plasticity and easy processing. The degradation period is 2~12 months. The degradation cycle can also be changed according to the addition of different modifiers. PLLA is decomposed by enzymes in the organism and eventually forms carbon dioxide and water, which has good biological compatibility.

PLLA is one of the most popular materials in the domestic medical beauty market. When Poly(L-Lactic Acid) (PLLA) goes into the depth of the skin, it will continue to induce human fibroblasts to secrete synthetic collagen. The newly produced collagen will gradually fill up the volume of the original missing part and repair the elastic network of the skin, which can fade facial wrinkles and hollows from inside out and from light to dark, making the skin look young again. So as to achieve anti-aging effect.

Poly-l-lactic acid (PLLA) microspheres are regenerative materials, endogenous stimulation of collagen regeneration, collagen will naturally fill the volume of the depression, the effect is real and natural, and the microspheres in the human body to degrade metabolites and the path is clear, there will be no crosslinking agent residue caused by the facial “slowness”, stiffness and other conditions.

PLLA has many uses and is widely used in the medical field, such as disposable infusion equipment and non-disassembly surgical sutures. Drug controlled release, slow release packaging agent; Tissue engineering scaffolds, bone fixation and bone repair materials, microcapsules for injection, microspheres, implants and animal organ support elastomers and other materials.

Processing technology: injection molding, electrospinning, etc.

Let’s talk about the specific uses of PLLA:

1. PLLA is applied to skin tissue

Collagen is one of the important structural proteins in the human body, which mainly exists in skin, bone, muscle, blood vessels and other tissues. PLLA can stimulate the production of collagen, which has the role of promoting skin regeneration and repair. Therefore, PLLA can be used in clinical treatment of skin trauma, burn and other tissue injuries to promote tissue repair and regeneration.

In addition, PLLA has also made a mark in the field of medical cosmetology. PLLA is the “anti-aging dark horse” in the medical beauty field, which solves the problem of lack of water in the dermis and loss of collagen from the root, makes the skin cells become plump, and the skin returns to the optimal state of full moisture, fine and smooth.

In the past two years, the concept of “regeneration” has been heated by the medical beauty market, and the “Tong Yan needle” produced by PLLA has become a supernova filled with medical beauty injections, and has been popular in the domestic medical beauty market in recent years. Compared with ordinary injectable fillers, PLLA has active regenerative properties and can achieve anti-aging effects by stimulating self-generated collagen. Studies have shown that the amount of collagen fibrin began to increase 3 months after PLLA was introduced into the body, and the amount of collagen fibrin increased significantly after 6 months. Collagen fibrin was continuously observed around PLLA particles for 8 to 24 months.

2. PLLA is used for skeletal tissue

The regeneration and repair of large area bone defects has always been an urgent problem in clinical practice. The complications caused by bone transplantation have severely limited the current treatment options. PLLA has a wide range of applications in bone repair, because of its similar physical and chemical properties to bone tissue, PLLA can be used to make bone scaffolds, bone nails and other bone repair materials. Studies have shown that combining PLLA with bioactive substances, such as bone morphogenetic proteins, osteoblasts, etc., can promote the bone regeneration and bone healing process, thereby accelerating the healing of fractures.

At present, the bone repair material industry is one of the more popular areas in the medical device industry, the market demand and competition are fierce, and the development momentum is rapid. The market size of bone repair materials is expanding year by year, mainly influenced by factors such as the increasing aging population and the increasing number of patients with fractures and bone defects. According to statistics, the global market for bone repair materials was about $30 billion in 2019 and is expected to reach $50 billion by 2025.

3. PLLA is applied to vascular tissue

PLLA plays an important role in the preparation of vascular stents. Vascular stent is a kind of material used to repair or replace damaged blood vessels. As a biodegradable polymer, PLLA can gradually degrade and be metabolized by human body, and fuse with vascular tissues to eventually form new blood vessels.

PLLA can also be used as a cell carrier in vascular tissue engineering. Cell carrier is a material that can provide a good growth environment and promote cell attachment and expansion. PLLA can provide a suitable physiological environment for cells, and at the same time, it can gradually degrade and release bioactive substances such as growth factors to promote the regeneration of vascular tissue. By co-culture PLLA with cells, the adhesion and proliferation ability of cells on the surface of the material can be improved, so as to realize the reconstruction and repair of vascular tissue.

PLLA can also be used for stent surface modification in vascular tissue engineering. The modification of scaffold surface can change its surface properties, such as surface roughness and hydrophilicity, so as to affect the adhesion and growth behavior of cells.

4. PLLA is used for cartilage tissue

PLLA nanofiber scaffolds manufactured by phase separation combined with pore-inducing agent leaching have been shown to be the preferred solution for various in vivo and in vitro cartilage repair. This is due to the high porosity and interoperability of these scaffolds, as well as their good degradability properties. In addition, the proper size of the scaffold hole also improves the functional characteristics of cartilage, thus providing some different solutions for the regeneration and repair of cartilage tissue.

Cartilage repair is a rapidly developing field with huge market prospects. With the increasing trend of population aging, the demand for cartilage repair and bioactive materials will continue to increase.

Unilong offers a wide range of PLLA product types with different viscosities:

Name Intrinsic viscosity range

dL/g

PLLA 0.30-0.50
PLLA 0.50-0.70
PLLA 0.70-1.00
PLLA 1.00-1.50
PLLA 1.50-2.00
PLLA 2.00-2.50
PLLA 2.50-3.00
PLLA 3.00-4.00
PLLA 4.00-5.00

Storage method:

This series of products are biodegradable materials. During storage, avoid contact with water, acidic substances, alkaline substances, alcohol reagents and other reagents that can cause product degradation.

Moreover, PLLA materials have long been recognized as one of the synthetic polymer materials suitable for tissue engineering. Its nanofiber scaffolds can be used for specific tissue engineering applications, including skin tissue regeneration, blood vessels, cartilage, bone, etc., so the market prospects are very broad.

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Unilong®️ Group specializes in the research, development, production and operation of biological materials and green solvents. It is a high-tech enterprise integrating the research, development and production of new environmentally friendly and degradable materials.

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