What is the PLGA

In recent years, the medical beauty industry has been booming, and more and more people have begun to pursue beauty and health. However, traditional beauty methods often can only temporarily improve skin problems, and regenerative materials have become a trend of concern. Regenerative material medical beauty uses the body’s own regenerative ability, through injection or surgery, etc., to bring people a more durable, natural beauty effect.

Traditional filling materials, such as hyaluronic acid, collagen fillers, etc., are just physical placeholder volume filling, filling the depressed space, and waiting for complete absorption and metabolism will completely return to its original shape. However, the recycled materials can also stimulate the regeneration of our own collagen while helping us fill. After the filling is thoroughly metabolized and absorbed, the collagen we grow can fill the original tissue loss and continue to increase and repair the appearance. Compared with traditional filling materials, the advantages of recycled materials are very obvious. In the medical beauty industry, we mainly use recycled materials including PLLA, PLGA, PCL and so on. Today, we mainly introduce PLGA produced by Unilong Group.

What is the PLGA?

Poly(D,L-Lactide-Co- Glycolide) (PLGA) is randomly polymerized from two monomers lactic acid and glycolic acid. As a biodegradable biomedical polymer, it has good biocompatibility, can be completely degraded and absorbed in the human body, and the material degradation time is controllable, which can be designed according to different product needs. In the pharmaceutical industry, PLGA can be widely used in medical sutures, drug controlled release systems, tissue engineering and bone fixation materials. In the United States, PLGA has been approved by the FDA and is included in the United States Pharmacopoeia as a pharmaceutical excipient.

PLGA is a random copolymer, amorphous polymer, widely used in surgical sutures, anti-adhesion membranes, tissue engineering scaffolds, can absorb microspheres, such as drug-loaded sustained-release microspheres. Compared with PLA, the polymer degradation time can be controlled according to the different GA content, and the material is soft and flexible. Different monomer ratios can produce different types of PLGA, for example: PLGA 75:25 indicates that the polymer is composed of 75% lactic acid and 25% glycolic acid.The degradation degree of PLGA varies with the monomer ratio, and the higher the proportion of ethyl ester, the easier the degradation.

PLGA has good biocompatibility and can be completely degraded and absorbed in vivo. The material degradation time is controllable and can be designed according to product needs. The molecular weight is controllable, and the molecular weight distribution is less than 1.5.

What Is PLGA Used For? 

1.Medical sutures
Due to its biodegradability, PLGA can be automatically degraded and absorbed after wound healing, without the need for second surgery, no need to remove stitches, no stimulation to the wound, and can effectively promote healing
2. Drug controlled release system
The degradation products of PLGA are lactic acid and glycolic acid, and when it is used in medicine and biological materials, it will not produce toxic side effects. In addition, the biggest advantage of PLGA polymer is that it can adjust the proportion of monomers, and then change the degradation time of PLGA, control the release rate of drugs (PLGA release time can be from a few days to 12 months or more), achieve the purpose of continuous release of drugs, and reduce the level of drugs in the body. At the same time, PLGA can biodegrade, avoiding the secondary damage and other troubles caused by taking the carrier out of the body.
In terms of safety, PLGA as a drug delivery carrier has many years of clinical use experience, with low recurrence rate, high compliance, and few adverse reactions. PLGA is widely used in drug microspheres because of its good processing and controlled release properties.

3. Tissue engineering and bone internal fixation materials
Bone tissue regeneration, cartilage tissue regeneration, artificial skin, peripheral nerve repair and other materials made of PLGA are non-toxic in the body, have good biocompatibility, will not cause inflammation of surrounding tissue, no rejection reaction, and can be biodegraded, can participate in the carbohydrate metabolism cycle in the human body, no residue. Application example – Absorbable bionic artificial bone.

With the rapid development of biomedical materials industry, PLGA, as a kind of biomedical polymer with excellent performance, has shown great development potential. Unilong Industry Co.,Ltd. has many advantages in the research and development and application of polylactic acid, polycaprolactone and related copolymers for many years. We also have our own brand Uli-Eco, which can provide biomedical materials and equipment processing services for users in need.

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Unilong®️ Group specializes in the research, development, production and operation of biological materials and green solvents. It is a high-tech enterprise integrating the research, development and production of new environmentally friendly and degradable materials.

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