Where does glycolide come from?

Glycolide, referred to as GA, is a biodegradable material with a molecular formula of C4H4O4. As a polymerizing monomer, it can be homopolymerized to obtain polyglycolide, or it can be ring-opening copolymerized with other cyclic monomers to obtain random copolymers or block copolymers, which are a type of biodegradable polymer materials. , gradually attracted attention from the medical field.

It has excellent physical and chemical properties and biocompatibility and plays an important role in the research and development of medical polymer materials. It is used in many fields such as surgical sutures, artificial skin and blood vessels, bone fixation and repair, drug controlled release, tissue engineering, etc. been applied.

As a biodegradable material, glycolide can be used as a drug carrier to effectively extend the drug’s action time and release rate. Studies have found that glycolide can control the release rate of drugs, improve their bioavailability, and reduce their side effects. Therefore, the application prospects of glycolide in drug carriers such as microcapsules and nanoparticles are very broad.

The application of glycolide in the fields of drug development and biotechnology has also received widespread attention from researchers. Glycolide can be used as an efficient drug carrier to improve the stability and solubility of drugs and reduce the toxic and side effects of drugs. In addition, glycolide can also be used to synthesize biotechnology products such as peptide drugs and protein drugs to promote the development and application of biotechnology.

Glycolide production process

The production of glycolide is mainly achieved through esterification reaction, that is, ethanol and acetic acid pass through a catalyst

function to produce glycolide and water. The chemical equation of this reaction is:

Acetic acid + ethanol → glycolide + water

The production process of caprolactide can generally be divided into the following steps:

1.Raw material preparation: The main raw materials for the production of glycolide are ethanol and acetic acid

2.Esterification reaction

3.Separation and purification

4.Impurity removal and distillation

5.Exhaust gas treatment

There are two ways to prepare glycolide. The first way is to react with each other between glycolic acid molecules to produce polyglycolic acid with a lower molecular weight through esterification and dehydration. The polyglycolic acid is cracked and cyclized at high temperature to form glycolide.

The second approach is to use metal salts of haloacetic acids such as potassium to remove metal halides to generate glycolide.

At the end of the article, I will tell you how Unilong should store monoglycolide?

Storage method:

■ This series of products is made of biodegradable materials. During storage, contact with water, acidic substances, alkaline substances, alcohol reagents and other reagents that can cause product degradation should be avoided.

■ During the storage process, this series of products should be sealed, dried and stored at low temperature (refrigerator -20 degrees), and should be sealed with a sealing machine (remaining products after use must not be packaged and stored in ziplock bags).

■ When using, take it out of the refrigerator and place it at room temperature. Wait until the temperature reaches room temperature and wipe off the condensed moisture on the surface of the packaging bag before opening it (take it out of the refrigerator and open it at a constant temperature, and the moisture in the air will condense on the surface of the product, causing the product to degrade). The ambient air humidity during use should be less than 35% to prevent remaining products from getting damp and affecting product quality.

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Unilong®️ Group specializes in the research, development, production and operation of biological materials and green solvents. It is a high-tech enterprise integrating the research, development and production of new environmentally friendly and degradable materials.

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